This study was carried out to determine the effect of different irrigation treatmants and economic analysis on surface and subsurface methods in quinoa under the Mediterranean climate conditions at the experimental fields of the Çukurova University during 2016 and 2017 growing seasons in Turkey. In the study, surface drip and subsurface drip methods and four irrigation strategies (Full irrigation, FI; conventional deficit irrigation, DI-50 and DI-75; and Partial Root-Zone Drying, PRD-50 of full irrigation treatments) also a rain-fed treatment (RF) were considered. The experimental design was split plots with four replications. There was no significant differences in yields between surface and subsurface drip irrigation methods for quinoa however, different irrigation treatments resulted significantly (P<0.01) for yields. FI, RDI, DI-75, and PRD-50 treatments resulted significantly (P<0.01) greater quinoa grain yields than DI-50 and RF. Maximum yield was obtained from the FI treatment as 2906 and 2468 kg ha-1; and the lowest yield was obtained from the rainfed treatment (RF) as 2204 and 1855 kg ha-1, in the experimental years, respectively. Net profit ranged between 4954 to 8493 $ ha-1 in 2016 and 3270 to 5906 $ ha-1 in 2017 according to the irrigation treatments. Full irrigation treatment (FI) under surface drip irrigation method generated the highest net profit.