Urfa pepper which is different consumption pattern is a consumption and export product for our country. However, due to the drought in recent years, the yield and quality of Urfa pepper have decreased. In this study, it was aimed to determine the K, Ca, Mg, chlorophyll contents and the changes in CAT, SOD and APX activities of Urfa pepper under drought stress. Gölpınar, Hilvan, Osmanbey genotypes used in Şanlıurfa region and İnan 3363 standard pepper varieties were used in the study. Pepper seeds were planted in plastic pots containing 1 liter of soil and two seeds were planted in each pot. After the cotyledon leaves emergence, one plant was left in every pot. When plants were 30 days old seedlings, irrigation was stopped and no water was given for 19 days to drought application plants. The irrigation were continued according to their needs in control plant. The average temperature of climate room in which the study was conducted was measured as 23 OC in day time, 18 OC in night time and the light intensity was measured as 8000 lux. At the end of study which dsayned according to the randomized experimental design, it was determined that Gölpınar and Hilvan genotypes were tolerant to drought stress, while pepper varieties of İnan 3363 were sensitive.