This research was carried out to determine the effects of mineral fertilizer applications applied in different doses on disease severity according to phenological periods in some bread wheat varieties. In this study, bread wheat varieties (Bayraktar 2000, Demir 2000, Eser and Kenanbey) were used as plant materials. In the study, different doses of Fe (Fe5, Fe10, Fe20) and Zn (Zn7.5, Zn15, Zn30) and their combination Fe+Zn (Fe+Zn (5+7.5), Fe+Zn (10+15)), in the period from tillering to stalking were investigated. When compared to the variety without fertilizer application in general, Eser, one of the bread varieties, caused a decrease in disease severity in all Fe dose applications, while Zn applications caused an increase in the early period and both an increase and a decrease in the late periods. Bayraktar variety caused an increase in disease severity in all Fe dose applications in all phenological periods and in all zinc applications except the Zn7.5 dose. In the Kenanbey cultivar, Fe dose applications caused an increase in disease severity in all periods except the mid-late period, and zinc applications caused a decrease in disease in all periods except the early period. Variable increases and decreases were observed in all phenological periods in Demir 2000 variety. In the future, the effects of Fe and Zn, as well as other plant nutrients, will be studied. Disease development for local varieties can be revealed for different phenological periods and their accuracy can be increased.